Approaches to Antibiotics
Selected Readings
Questions
Solving Problems in Bacterial Pathogenesis
Special Global Perspective Problems: Integrating Concepts in Pathogenesis
CHAPTER 17 Vaccination: A Critical Component of the Modern Medical Armamentarium
Vaccines: A Major Health Care Bargain
What Makes an Ideal Vaccine?
Immunization Programs
Barriers to Implementation and Success of Immunization Programs
The Antivaccination Movement
Vaccine Success Stories
Subunit Vaccines
Conjugate Vaccines
Vaccine “Less-than-Success” Stories
A New Age of Vaccine Development: Making Vaccines Better
Approaches to Enhancing Immunogenicity
Adjuvants
Programming Adaptive Immunity
Targeting Mucosal Immunity
Storage of Vaccines—Strategies to Increase Shelf Life
Passive Immunization
Selected Readings
Questions
Solving Problems in Bacterial Pathogenesis
Special Global Perspective Problems: Integrating Concepts in Pathogenesis
CHAPTER 18 The Gram-Positive Opportunistic Pathogens
What Is an Opportunist?
Characteristics of Gram-Positive Opportunists
Notable Gram-Positive Opportunists
Staphylococcus aureus—Commensal Ready for a Fight
Staphylococcus epidermidis—Accidental Pathogen
Streptococcus pneumoniae—“Captain of All the Men of Death”
Clostridium difficile—True Opportunist
Other Gram-Positive Opportunists
Selected Readings
Questions
Solving Problems in Bacterial Pathogenesis
CHAPTER 19 The Gram-Negative Opportunistic Pathogens
Jumping Over the (Cell) Wall: Gram-Negative Bacteria Can Be Opportunistic Pathogens Too!
Common Traits of Gram-Negative Opportunists
The Dark Side of Some Residents of the Human Body
The Ever-Changing Face of E. coli
Klebsiella pneumoniae Nosocomial Infections
Bacteroides fragilis—The Bad Sheep of the Family
Porphyromonas gingivalis—A Keystone Pathogen
Environmental Inhabitants Weigh in as Opportunists
Pseudomonas aeruginosa—A Versatile Opportunist of the Highest Order
Burkholderia cepacia Complex—P. aeruginosa’s Evil Twin
Acinetobacter baumannii—A Deadly Threat Emerges from the Iraq War
Don’t Forget the Arthropods!
Ehrlichia spp.
Selected Readings
Questions
Solving Problems in Bacterial Pathogenesis
Special Global Perspective Problems: Integrating Concepts in Pathogenesis
CHAPTER 20 The Changing Roles of Microbiologists in an Age of Bioterrorism and Emerging Diseases
When Microbiologists Are Called to the Front Line
Tracking Down a Bioterrorist
Unintentional or Deliberate?
Timing
Tracing the Source
Lessons Learned
The “Top Four” Bioterror Agents
Bacillus anthracis Spores
Smallpox
Yersinia pestis
Botulinum Neurotoxin
What If Bioterrorists Hit Us with Something Completely New?
Biosecurity in a Complex, Dynamic, and Ever-Changing World
Food Safety and Biosecurity
The Case for Food Irradiation
The Future of Biosecurity
Selected Readings
Questions
Solving Problems in Bacterial Pathogenesis
Preface
Since
