Secondary Metabolites of Medicinal Plants. Bharat Singh
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38 Rojatkar, S.R. and Nagasmpaki, B.A. (1994). 11α-hydroxy-12-norazadirachtin from Azadirachta indica (A. Juss.). Nat. Prod. Lett. 5: 69–76.
39 Rout, G.R. (2005). In vitro somatic embryogenesis in callus cultures of Azadirachta indica A. Juss. – a multipurpose tree. J. For. Res. 10: 263–267.
40 Salvi, N.D., Singh, H., Tivarekar, S., and Eapen, S. (2001). Plant regeneration from different explants of neem. Plant Cell Tissue Organ Cult. 65: 159–162.
41 Sanyal, M., Das, A., Banerjee, M., and Datta, P.C. (1981). In vitro hormone induced chemical and histological differentiation in stem callus of neem (Azadirachta indica A. Juss.). Indian J. Exp. Biol. 19: 1067–1068.
42 Satdive, R.K., Fulzele, D.P., and Eapen, S. (2007). Enhanced production of azadirachtin by hairy root cultures of Azadirachta indica A. Juss by elicitation and media optimization. J. Biotechnol. 128: 281–289.
43 Satdive, R.K., Eapen, S., and Fulzele, D.P. (2011). Bioactive constituents and antimicrobial activity of cell cultures of Azadirachta indica. Int. J. Pharm. Bio. Sci. 2: 617–628.
44 Savitha, B.C., Timmaraju, R., Bhagyalakshmi, N., and Ravishankar, G.A. (2006). Different biotic and abiotic elicitors influence betalain production in hairy root cultures of Beta vulgaris in shake flask and bioreactor. Process Biochem. 41: 50–60.
45 Saxena, N. and Kumar, Y. (2008). Chemistry of azadirachtin and other bioactive isoprenoids from neem. In: Neem: A Treatise (eds. K.K. Singh, S. Phogat, A. Tomar and R.S. Dhillon), 175–198. New Delhi: IK International.
46 Schaaf, O., Jarvis, A.P., van der Esch, S.A. et al. (2000). Rapid and sensitive analysis of azadirachtin and related triterpenoids from neem (Azadirachta indica) by high-performance liquid chromatography–atmospheric pressure chemical ionization mass spectrometry. J. Chromatogr. A 886: 89–97.
47 Sharma, V., Walia, S., Kumar, J. et al. (2003). An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS. J. Agric. Food. Chem. 51: 3966–3972.
48 Siddiqui, S., Faizi, S., and Siddiqui, B.S. (1986). Studies on the Chemical Constituents of Azadirachta indica A. Juss (Meliaceae), Part VII [1]. Z. Naturforsch. 41b: 922–924.
49 Singh, M. and Chaturvedi, R. (2013). Sustainable production of azadirachtin from differentiated in vitro cell lines of neem (Azadirachta indica). AoB Plants 5 https://doi.org/10.1093/aobpla/plt034.
50 Solomon, K.A., Malathi, R., Rajan, S.S. et al. (2005). The isomeric compounds nimbolide and isonimbolide. Acta Crystallogr. C 61: 70–72.
51 Srividya, N. and Devi, B.P.S. (1998). Azadirachtin and nimbin content in in vitro cultured shoots and roots of Azadirachta indica A. Juss. Indian J. Plant Physiol. 3: 129–134.
52 Subapriya, R. and Nagini, S. (2005). Medicinal properties of neem leaves: a review. Curr. Med. Chem. Anticancer Agents 5: 149–156.
53 Sujanya, S., Devi, B.P., and Sai, I. (2008). In vitro production of azadirachtin from cell suspension cultures of Azadirachta indica. J. Biosci. 33: 113–120.
54 Vani, M.M., PSS, R., Varma, G.N. et al. (2016). Identification and chemical characterization of Azadirachta indica leaf extracts through thin layer chromatography. Int. J. Res. Eng. Technol. 5: 117–122.
55 Veerasham, C., Rajkumar, N., Sowjanya, D. et al. (1998). Production of azadirachtin from callus cultures of Azadirachta indica. Fitoterapia 69: 423–424.
56 Wewetzer, A. (1998). Callus cultures of Azadirachta indica and their potential for the production of azadirachtin. Phytoparasitica 26: 47–52.
57 Yamasaki, R.B., Klocke, J.A., Lee, S.M. et al. (1986). Isolation and purification of azadirachtin from neem (Azadirachta indica) seeds using flash chromatography and high-performance liquid chromatography. J. Chromatogr. A 356: 220–226.
2.17 Bryophyllum Species
2.17.1 Ethnopharmacological Properties and Phytochemistry
Bryophyllum pinnatum (Lam.) Kurz. (syn. Kalanchoe pinnata; Fam. –Crassulaceae) is used for medicinal purposes in Indochina regions and naturalized throughout the hot and moist parts of India. The leaves and bark are known as bitter tonic, astringent to the bowels, analgesic, and carminative and useful in diarrhea and vomiting (Kirtikar and Basu 1975; Chopra et al. 1992) and for relieving the pains and inflammations, as well as earaches, stomach ulcers, flu, and fever (Da Silva et al. 1995). The leaf juice possessed antiviral, antipyretic, antimicrobial, anti-inflammatory, antitumor, hypocholesterolemic, antioxidant, diuretic, antiulcer, styptic, antidiabetic, astringent, antiseptic, antilithic, and cough suppressant effects (Huang 1993; Nadkarni 1988; Asolkar et al. 1992). The leaves of Kalanchoe crenata, taken as remedy during pregnancy by women (Malan and Neuba 2011), are recommended to heal umbilical cord wounds in newborns (Tugume et al. 2016). Kalanchoe daigremontiana is prescribed for anthroposophic medications, administered against psychic agitation and restlessness (Süsskind et al. 2012), Kalanchoe densiflora for the healing of wounds (Bussmann 2006), and Kalanchoe germanae for removal of ganglion (Kipkore et al. 2014). Kalanchoe gracilis helps in curing injuries, pain, fever, and inflammation (Lai et al. 2010). Kalanchoe laciniata leaf juice is used externally for relieving joint pain (Karuppusamy 2007). The powdered leaves are administered to alleviate cough, to cure colds and inflammation, and for healing of boils and wounds, while crushed leaves are applied externally to decrease body temperature and to heal ulcers (Deb and Dash 2013). Kalanchoe lanceolata is used as antimalarial agent (Njoroge and Bussmann 2006). The leaf juice is administered for dysentery (Bapuji and Ratnam 2009), Kalanchoe marmorata boiled juice is used as eye drops for treatment of eye infections (Belayneh and Bussa 2014), Kalanchoe petitiana leaf juice is applied on the fractured for bone setting (Ragunathan and Abay 2009). The leaves of B. pinnatum possessed antimicrobial (Mehta Bhat 1952; Akinpelu 2000), antifungal (Misra and Dixit 1979), antiulcer (Pal and Nag Chaudhari 1991), anti-inflammatory (Pal and Nag Chaudhari 1989, 1992), analgesic, antihypertensive (Ojewole 2002), potent antihistamine, and anti-allergic activities (Pal et al. 1999). In Peru, tribal people mix the leaf with sugarcane rum and apply the paste to the temples for headaches; they soak the leaves and stems overnight in cold water for urethritis, fever, and other related problems. The infusion of roots is used for treatment of epilepsy (Kamboj and Saluja 2009). The leaf press juice of B. pinnatum induced the relaxation in carbachol-induced contractions, but the effect was lower than with oxybutynin (reference compound). It has been established that leaf press juice might offer a new treatment option for patients with overactive bladder (Schuler et al. 2012; Betschart et al. 2013; Fürer et al. 2015). The leaves of B. pinnatum possess antidiabetic (Ojewole 2005), antihypertensive (Ojewole 2002), antimicrobial (El Abdellaoui et al. 2010; Akinpelu 2000), antifungal (Misra and Dixit 1979), anti-asthmatic (Ozolua et al. 2010), cytotoxic (El Abdellaoui et al. 2010), antiurolithic (Yasir and Waqar 2011), antioxidant (Gupta and Banerjee 2011), cardioprotective (Wachter et al. 2011), neurosedative, and muscle relaxant activities (Yemitan and Salahdeen 2005).
Quercitrin was obtained from aqueous extract of K. pinnata and demonstrated antileishmanial activity (Muzitano et al. 2006b). The kalantuboside A and kalantuboside B have been identified from Kalanchoe tubiflora (Huang et al. 2013). K. lanceolata showed the presence of lanceotoxin A and lanceotoxin B (Anderson et al. 1984). Kalanhybrins A, B, and C were identified from Kalanchoe hybrida (Kuo et al. 2008). 3β-(40,60-Dideoxy-barabino-hexopyranosyloxy)-2β-acetoxy-5b,14β-dihydroxy-19-oxobufa-20,22-dienolide was isolated