Human Metabolism. Keith N. Frayn

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Human Metabolism - Keith N. Frayn

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critical illness myopathy CIP critical illness polyneuropathy CNP C-type natriuretic peptide CNS central nervous system CoA coenzyme A CoASH coenzyme A reduced form CoQ10 ubiquinone CPT-1, 2 carnitine-palmitoyl transferase-1, 2 CSII continuous subcutaneous insulin infusion DHA docosahexaenoic acid (22 : 6 n-3) D-2HG D-2-hydroxyglutarate DIT diet-induced thermogenesis DPP Diabetes Prevention Program EDRF endothelial-derived relaxing factor EE energy expenditure eIF eukaryotic initiation factor eNOS endothelial NO synthase ER endoplasmic reticulum ERK extracellular signal-regulated kinase FABP(pm) fatty acid binding protein (plasma membrane isoform) FAD flavin adenine dinucleotide (oxidised form) FADH2 flavin adenine dinucleotide (reduced form) FAT fatty acid translocase FATP fatty acid transport protein FFM fat-free mass FGF fibroblast growth factor FH familial hypercholesterolaemia FIL feedback inhibitor of lactation FoxO Forkhead box ‘Other’ FQ food quotient FSH follicle-stimulating hormone FXR farnesoid X-receptor G Gibbs ‘free’ energy G6-P glucose 6-phosphate GDP guanosine 5′-diphosphate GH growth hormone GHSR growth hormone secretagogue receptor GIP gastric inhibitory polypeptide, also known as glucose-dependent insulinotrophic polypeptide GK glucokinase GLP (1 and 2) glucagon-like peptide-1 and -2 GLUT glucose transporter GOAT ghrelin-O-acyltransferase GPAT glycerol phosphate-acyl transferase GPCR G protein-coupled receptor GPIHBP1 glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 GR glucocorticoid receptor GSK glycogen synthase kinase GTP guanosine 5′-trisphosphate HDAC histone deacetylation/deacetylase HDL high density lipoprotein HIF-1 hypoxia-inducible factor-1 HIV Human Immunodeficiency Virus HK hexokinase HMG-CoA 3-hydroxy-3-methylglutaryl-CoA hPL human placental lactogen HSL hormone-sensitive lipase 5-HT 5-hydroxytryptamine IDDM insulin-dependent diabetes mellitus IGF insulin-like growth factor IL interleukin IMM inner mitochondrial membrane JAK originally Just Another Kinase; redesignated JAnus Kinase K a dissociation constant for an acid K m Michaelis constant LADA latent autoimmune diabetes in adults LCAD long-chain acyl CoA dehydrogenase LCAT lecithin-cholesterol acyltransferase LDL low-density lipoprotein LH luteinising hormone LPL lipoprotein lipase LXR liver X-receptor MAPK mitogen-activated protein kinase MET (unit of work): 1 MET = resting metabolic rate MI myocardial infarction MODS multiple organ dysfunction syndrome

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