Principles of Virology, Volume 2. S. Jane Flint

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Chase Cancer Center

      Philadelphia, Pennsylvania

       Theodora Hatziioannou

      The Rockefeller University

      New York, New York

       Anna Marie Skalka

      Fox Chase Cancer Center

      Philadelphia, Pennsylvania

      Copublication by the American Society for Microbiology and John Wiley & Sons, Inc.

      No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted by law. Advice on how to reuse material from this title is available at http://wiley.com/go/permissions.

      The right of Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Theodora Hatziioannou, and Anna Marie Skalka to be identified as the author(s) of this work/the editorial material in this work has been asserted in accordance with law.

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      While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy of completeness of the contents of this book and specifically disclaim any implied warranties or merchantability of fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The publisher is not providing legal, medical, or other professional services. Any reference herein to any specific commercial products, procedures, or services by trade name, trademark, manufacturer, or otherwise does not constitute or imply endorsement, recommendation, or favored status by the American Society for Microbiology (ASM). The views and opinions of the author(s) expressed in this publication do not necessarily state or reflect those of ASM, and they shall not be used to advertise or endorse any product.

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       Library of Congress Cataloging-in-Publication Data

      Names: Flint, S. Jane, author. | Racaniello, V. R. (Vincent R.), author. | Rall, Glenn F., author. | Hatziioannou, Theodora, author. | Skalka, Anna Marie, author.

      Title: Principles of virology / Jane Flint, Department of Molecular Biology, Princeton University, Princeton, New Jersey, Vincent R. Racaniello, Department of Microbiology & Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, Glenn F. Rall, Fox Chase Cancer Center, Philadelphia, Pennsylvania, Theodora Hatziioannou, The Rockefeller University, New York, New York, Anna Marie Skalka, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

      Description: Fifth edition. | Washington, DC : American Society for Microbiology [2020] ; Hoboken, NJ : Wiley, [2020] | Includes bibliographical references and index. | Contents: volume 1. Molecular biology—volume 2. Pathogenesis and control.

      Identifiers: LCCN 2020013722 (print) | LCCN 2020013723 (ebook) | ISBN 9781683670322 (set) | ISBN 9781683672845 (v. 1 ; paperback) | ISBN 9781683672852 (v. 2 ; paperback) | ISBN 9781683672821 (v. 1 ; adobe pdf) | ISBN 9781683673606 (v. 1 ; epub) | ISBN 9781683672838 (v. 2 ; adobe pdf) | ISBN 9781683673590 (v. 2 ; epub) | ISBN 9781683670339 (adobe pdf) | ISBN 9781683673583 (epub)

      Subjects: LCSH: Virology.

      Classification: LCC QR360 .P697 2020 (print) | LCC QR360 (ebook) | DDC 616.9/101—dc23

      LC record available at https://lccn.loc.gov/2020013722

      LC ebook record available at https://lccn.loc.gov/2020013723

      Illustrations and illustration concepting: Patrick Lane, ScEYEnce Studios

      Cover image: Visual Science

      Cover and interior design: Susan Brown Schmidler

       We also dedicate it to our families:Jonn, Gethyn, and Amy LeedhamDoris, Aidan, Devin, and NadiaEileen, Kelsey, and AbigailPaul, Stefan, and EveRudy, Jeannie, and Chris

       Oh, be wiser thou!Instructed that true knowledge leads to love.

      WILLIAM WORDSWORTH

      Lines left upon a Seat in a Yew-tree 1888

      This book is accompanied by a companion website:

      www.wiley.com/go/flint/pov5

      The website includes:

       PowerPoints of figures

       Author podcasts

       Study Questions and Answers

       The enduring goal of scientific endeavor, as of all human enterprise, I imagine, is to achieve an intelligible view of the universe. One of the great discoveries of modern science is that its goal cannot be achieved piecemeal, certainly not by the accumulation of facts. To understand a phenomenon is to understand a category of phenomena or it is nothing. Understanding is reached through creative acts.

      A. D. HERSHEY

       Carnegie Institution Yearbook 65

      All five editions of this textbook have been written according to the authors’ philosophy that the best approach to teaching introductory virology is by emphasizing shared principles. Studying the common steps of the viral reproductive cycle, illustrated with a set of representative viruses, and considering mechanisms by which

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