STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGG
STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGM
STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGA
STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGD
STRUCTURAL AND BIOLOGICAL PROPERTIES OF IGE
KINETICS OF THE ANTIBODY RESPONSE FOLLOWING IMMUNIZATION
THE IMMUNOGLOBULIN SUPERFAMILY
ANTIGEN–ANTIBODY INTERACTIONS
SECONDARY INTERACTIONS BETWEEN ANTIBODY AND ANTIGEN
REFERENCES AND BIBLIOGRAPHY
REVIEW QUESTIONS
ANSWERS TO REVIEW QUESTIONS
16 7 ORGANIZATION AND EXPRESSION OF LYMPHOCYTE ANTIGEN RECEPTOR GENES INTRODUCTION A BRIEF REVIEW OF GENE STRUCTURE AND GENE EXPRESSION B‐CELL ANTIGEN‐SPECIFIC RECEPTORS AND RECEPTOR GENES GENETIC EVENTS IN SYNTHESIS OF Ig CHAINS IMMUNOGLOBULIN CLASS SWITCHING GENERATION OF ANTIBODY DIVERSITY ROLE OF ACTIVATION-INDUCED CYTIDINE DEAMINASE IN GENERATING ANTIBODY DIVERSITY T‐CELL ANTIGEN‐SPECIFIC RECEPTORS AND RECEPTOR GENES GENES CODING FOR T‐CELL RECEPTORS GENERATION OF T‐CELL RECEPTOR DIVERSITY REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
17 8 THE MAJOR HISTOCOMPATIBILITY COMPLEX AND ANTIGEN PRESENTATION INTRODUCTION HOW THE MHC GOT ITS NAME MHC ROLE IN ANTIGEN PRESENTATION DIFFERENT MHC MOLECULES ARE EXPRESSED BY DISTINCT HOST CELLS AND INTERACT WITH DIFFERENT SETS OF T CELLS VARIABILITY OF MHC CLASS I AND MHC CLASS II MOLECULES STRUCTURE OF MHC CLASS I AND CLASS II MOLECULES ANTIGEN PROCESSING AND PRESENTATION: HOW MHC MOLECULES BIND PEPTIDES AND CREATE LIGANDS THAT INTERACT WITH T CELLS OTHER TYPES OF ANTIGEN THAT ACTIVATE T‐CELL RESPONSES GENES OF THE HLA REGION NOMENCLATURE OF POLYMORPHIC MHC MOLECULES REGULATION OF EXPRESSION OF MHC GENES MHC IN OTHER SPECIES DIVERSITY OF MHC MOLECULES: MHC ASSOCIATION WITH RESISTANCE AND SUSCEPTIBILITY TO DISEASE REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
18 9 B‐CELL DEVELOPMENT AND ACTIVATION INTRODUCTION DEVELOPMENT OF B LYMPHOCYTES GENETICS OF IMMUNOGLOBULIN GENE REARRANGEMENTS NEGATIVE SELECTION AND THE DEVELOPMENT OF CENTRAL TOLERANCE B‐CELL ACTIVATION B‐CELL MEMBRANE PROTEINS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
19 10 T‐CELL DEVELOPMENT AND ACTIVATION INTRODUCTION THE ANTIGEN‐SPECIFIC T‐CELL RECEPTOR GENES CODING FOR T‐CELL RECEPTORS GENERATION OF T‐CELL RECEPTOR DIVERSITY T‐CELL DIFFERENTIATION IN THE THYMUS ACTIVATION AND FUNCTION OF T CELLS A TWO‐SIGNAL MODEL FOR THE ACTIVATION OF T CELLS DENDRITIC CELLS ARE THE KEY APC FOR NAÏVE T CELLS ACTIVATION OF CD4+ T CELLS CD4+ T‐CELL FUNCTION ACTIVATION AND FUNCTION OF CD8+ T CELLS MEMORY T CELLS FUNCTION OF OTHER SUBSETS OF T CELLS REFERENCES AND BIBLIOGRAPHY REVIEW QUESTIONS ANSWERS TO REVIEW QUESTIONS
20 11 CYTOKINES INTRODUCTION THE HISTORY OF CYTOKINES
