Practical Cardiovascular Medicine. Elias B. Hanna

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style="font-size:15px;">      48 Answer 23. C. OCT helps show features of plaque erosion and SCAD. Plaque erosion is characterized by thrombus with an intact intimal cap or a fibrointimal plaque. However, when SCAD is suspected, it is best to avoid any coronary manipulation, including OCT, as each manipulation increases the risk of intramural hematoma propagation. When the flow is preserved and the disease is not critical, SCAD is best treated conservatively with no PCI. The majority of SCADs (70-97%) will heal by 1-2 months.

      49 Answer 24. B. Patients with true ACS/type 1 MI may have HTN secondary to the distress of angina. However, in the case presented here, the persistence of HTN and its requirement for multiple agents implies that malignant HTN is the primary process responsible for the patient’s pain and troponin rise. The severe LVH, seen on echo, accentuates ischemic demands and is a marker of uncontrolled HTN. The degree of troponin rise (< 1 ng/ml) is consistent with ischemic imbalance. Ischemic workup, possibly stress testing, may be performed once HTN is controlled and chest pain resolves.

      50 Answer 25. A. Compare this case to Question 24. The quick resolution of HTN with NTG implies that HTN was secondary to myocardial ischemia (catecholamine surge), rather than a cause of ischemia. Even the milder troponin rise, in context, is worrisome for true ACS and plaque rupture.

      Definition of MI, type 1 and type 2 MI

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      3 3. Keller T, Zeller T, Ojeda F, et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011; 306: 2684–93.

      4 4. Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [published online ahead of print, 2020 Aug 29]. Eur Heart J. 2020;ehaa575.

      5 5. Goldstein JA, Demetriou D, Grines CL, et al. Multiple complex coronary plaques in patients with acute myocardial infarction. N Engl J Med 2000; 343: 915–22.

      6 6. Alcalai R, Planer D, Culhaoglu A, et al. Acute coronary syndrome versus nonspecific troponin elevation. Arch Intern Med 2007; 167: 276–81.

      7 7. Tehrani DM, Seto AH. Third universal definition of myocardial infarction: update, caveats, differential diagnosis. Cleve Clin J Med 2013; 80: 777–86.

      8 8. Nestelberger T, Boeddinghaus J, Badertscher P, et al. Effect of definition on incidence and prognosis of type 2 myocardial infarction. J Am Coll Cardiol 2017; 70:1558–1568.

      9 9. Peacock WF, De Marco E, Fonarow GC, et al. Cardiac troponin and outcome in acute heart failure. N Engl J Med 2008; 258: 2117–26.

      10 10. Niemen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: Description of population. Eur Heart J 2006; 27: 2725–36.

      11 11. Baron T, Hambraeus K, Sundström J, et al (TOTAL-AMI study group). Impact on long-term mortality of presence of obstructive coronary artery disease and classification of myocardial infarction. Am J Med. 2016; 129:398–406 (SWEDEHEART registry).

      12 12. Chapman AR, Shah ASV, Lee KK, et al. Long-term outcomes in patients with type 2 myocardial infacrtion and myocardial injury. Circulation 2018; 137 (12):1236–1245. British registry, in which all type 2 MI, with or without CAD, had high non-cardiac mortality.

      Vasospasm

      1 13. Prinzmetal M, Kennamer R, Merliss R, et al. Angina pectoris. 1. A variant form of angina pectoris. Am J Med 1959; 27: 375–88.

      2 14. Prinzmetal M, Ekemecki A, Kennamer R, et al. Variant form of angina pectoris: previously undelineated syndrome. JAMA 1960; 174: 1791–800.

      3 15. Maseri A, Severi S, de Nes M, et al. “Variant” angina: one aspect of a continuous spectrum of vasospastic myocardial ischemia: pathogenetic mechanisms, estimated incidence and clinical and coronary arteriographic findings in 138 patients. Am J Cardiol 1978; 42: 1019–35.

      4 16. Ong P, Athanasiadis A, Borgulya G, et al. High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries: the ACOVA study (Abnormal COronary VAsomotion in patients with stable angina and unobstructed coronary arteries). J Am Coll Cardiol 2012; 59: 655–662.

      5 17. Ong P, Athanasiadis A, Hill S, et al. Coronary artery spasm as a frequent cause of acute coronary syndrome: the CASPAR (Coronary Artery Spasm in Patients with Acute Coronary Syndrome) study. J Am Coll Cardiol 2008; 52: 523–527.

      6 18. Montone RA, Niccoli G, Fracassi F, et al. Patients with acute myocardial infarction and non-obstructive coronary arteries: safety and prognostic relevance of invasive coronary provocative tests. Eur Heart J 2018; 39:91–98 (mean troponin 0.1 in this study).

      MINOCA diagnosis and prognosis

      1 19. Pasupathy S, Air T, Dreyer RP, Tavella R, Beltrame JF. Systematic review of patients presenting with suspected myocardial infarction and nonobstructive coronary arteries. Circulation 2015; 131:861–70.

      2 20. Reynolds HR, Maehara A, Kwong RY, et al. Coronary Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging to Determine Underlying Causes of Myocardial Infarction With Nonobstructive Coronary Arteries in Women. Circulation. 2021 Feb 16; 143(7):624–640. +Also: Reynolds HR, Srichai MB, Iqbal SN, et al. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation 2011; 124 (13): 1414–1425

      3 21. Gerbaud E, Arabucki F, Nivet H, et al. OCT and CMR for the Diagnosis of Patients Presenting With MINOCA and Suspected Epicardial Causes. JACC Cardiovasc Imaging. 2020 Dec; 13(12):2619–2631.

      4 22. Roe MT, Harrington RA, Prosper DM, et al. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease. Circulation 2000; 102: 1101–6.

      5 23. Tamis-Holland JE, Jneid H, Reynolds HR, et al. Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association. Circulation. 2019; 139(18):e891–e908.

      6 24. Rossini R, Capodanno D, Lettieri C, et al. Long-term outcomes of patients with acute coronary syndrome and nonobstructive coronary artery disease. Am J Cardiol 2013; 112: 150–5.

      7 25. Hirsch A, Windhausen F, Tijssen JGP, et al Diverging associations of an intended early invasive strategy compared with actual revascularization, and outcome in patients with non-ST-segment elevation acute coronary syndrome: the problem of treatment selection bias. Eur Heart J 2009; 30, 645–54.

      8 26. Leurent G, Langella B, Fougerou C, et al. Diagnostic contributions of cardiac magnetic resolution imaging in patients presenting with elevated troponin, acute chest pain syndrome, and unobstructed coronary arteries. Arch Cardiovasc Dis 2011; 104: 161–70.

      9 27. Assomull RG, Lyne JC, Keenan N, et al. The role of cardiovascular magnetic resonance in patients presenting with chest pain,

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