S., Lindqvist, C.M., Ito, G., Dolshanskaya, Y., Halfvarson, J., Franke, A., and Hemmrich-Stanisak, G. (2020). Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries. NAR Genom. Bioinform. 2: lqaa008.59 Juzwik, C.A.S.S.D., Zhang, Y., Paradis-Isler, N., Sylvester, A., Amar-Zifkin, A., Douglas, C., Morquette, B., Moore, C.S., and Fournier, A.E. (2019). microRNA dysregulation in neurodegenerative diseases: A systematic review. Prog. Neurobiol. 182: 101664.
60 Kagawa, T., Shirai, Y., Oda, S., and Yokoi, T. (2018). Identification of specific microRNA biomarkers in early stages of hepatocellular injury, cholestasis, and steatosis in rats. Toxicol. Sci. 166: 228–239.
61 Koberle, V., Pleli, T., Schmithals, C., Augusto Alonso, E., Haupenthal, J., Bonig, H., Peveling-Oberhag, J., Biondi, R.M., Zeuzem, S., Kronenberger, B., Waidmann, O., and Piiper, A. (2013). Differential stability of cell-free circulating microRNAs: Implications for their utilization as biomarkers. PLoS One 8: e75184.
62 Koenig, E.M., Fisher, C., Bernard, H., Wolenski, F.S., Gerrein, J., Carsillo, M., Gallacher, M., Tse, A., Peters, R., Smith, A., Meehan, A., Tirrell, S., and Kirby, P. (2016). The beagle dog microRNA tissue atlas: Identifying translatable biomarkers of organ toxicity. BMC Genom. 17: 649.
63 Kong, A.P., Xiao, K., Choi, K.C., Wang, G., Chan, M.H., Ho, C.S., Chan, I., Wong, C.K., Chan, J.C., and Szeto, C.C. (2012). Associations between microRNA (miR-21, 126, 155 and 221), albuminuria and heavy metals in Hong Kong Chinese adolescents. Clin. Chim. Acta. 413: 1053–1057.
64 Koppers-Lalic, D., Hackenberg, M., Bijnsdorp, I.V., Van Eijndhoven, M.A.J., Sadek, P., Sie, D., Zini, N., Middeldorp, J.M., Ylstra, B., De Menezes, R.X., Wurdinger, T., Meijer, G.A., and Pegtel, D.M. (2014). Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes. Cell Rep. 8: 1649–1658.
65 Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y., Takeshita, F., and Ochiya, T. (2013). Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J. Biol. Chem. 288: 10849–10859.
66 Kossinova, O.A., Gopanenko, A.V., Tamkovich, S.N., Krasheninina, O.A., Tupikin, A.E., Kiseleva, E., Yanshina, D.D., Malygin, A.A., Ven’Yaminova, A.G., Kabilov, M.R., and Karpova, G.G. (2017). Cytosolic YB-1 and NSUN2 are the only proteins recognizing specific motifs present in mRNAs enriched in exosomes. Biochim. Biophys. Acta Proteins Proteom. 1865: 664–673.
67 Kozomara, A., Birgaoanu, M., and Griffiths-Jones, S. (2019). miRBase: From microRNA sequences to function. Nucleic Acids Res. 47: D155–D162.
68 Krauskopf, J., Caiment, F., Claessen, S.M., Johnson, K.J., Warner, R.L., Schomaker, S.J., Burt, D.A., Aubrecht, J., and Kleinjans, J.C. (2015). Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury. Toxicol. Sci. 143: 268–276.
69 Krauskopf, J., Caiment, F., Van Veldhoven, K., Chadeau-Hyam, M., Sinharay, R., Chung, K.F., Cullinan, P., Collins, P., Barratt, B., Kelly, F.J., Vermeulen, R., Vineis, P., De Kok, T.M., and Kleinjans, J.C. (2018). The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution. Environ. Int. 113: 26–34.
70 Krauskopf, J., De Kok, T.M., Hebels, D.G., Bergdahl, I.A., Johansson, A., Spaeth, F., Kiviranta, H., Rantakokko, P., Kyrtopoulos, S.A., and Kleinjans, J.C. (2017). MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery. Sci. Rep. 7: 9262.
71 LaBelle, J., Bowser, M., Brown, A., Farnam, L., Kho, A., Li, J., Mcgeachie, M., Chase, R., Piehl, S., Allen, K., Hobbs, B.D., Weiss, S.T., Hersh, C., Tantisira, K., and Amr, S.S. (2021). Commercially available blocking oligonucleotides effectively suppress unwanted hemolysis related miRNAs in a large whole blood RNA cohort. J. Mol. Diagn. 23 (6): 671–682.
72 Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., and Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12: 735–739.
73 Lake, A.D., Wood, C.E., Bhat, V.S., Chorley, B.N., Carswell, G.K., Sey, Y.M., Kenyon, E.M., Padnos, B., Moore, T.M., Tennant, A.H., Schmid, J.E., George, B.J., Ross, D.G., Hughes, M.F., Corton, J.C., Simmons, J.E., Mcqueen, C.A., and Hester, S.D. (2016). Dose and effect thresholds for early key events in a PPARalpha-mediated mode of action. Toxicol. Sci. 149: 312–325.
74 Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A.O., Landthaler, M., Lin, C., Socci, N.D., Hermida, L., Fulci, V., Chiaretti, S., Foa, R., Schliwka, J., Fuchs, U., Novosel, A., Muller, R.U., Schermer, B., Bissels, U., Inman, J., Phan, Q., Chien, M., Weir, D.B., Choksi, R., De Vita, G., Frezzetti, D., Trompeter, H.I., Hornung, V., Teng, G., Hartmann, G., Palkovits, M., Di Lauro, R., Wernet, P., Macino, G., Rogler, C.E., Nagle, J.W., Ju, J., Papavasiliou, F.N., Benzing, T., Lichter, P., Tam, W., Brownstein, M.J., Bosio, A., Borkhardt, A., Russo, J.J., Sander, C., Zavolan, M., and Tuschl, T. (2007). A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129: 1401–1414.
75 Li, D., Knox, B., Gong, B., Chen, S., Guo, L., Liu, Z., Tong, W., and Ning, B. (2021). Identification of translational microRNA biomarker candidates for ketoconazole-induced liver injury using next-generation sequencing. Toxicol. Sci. 179: 31–43.
76 Li, L., Zhu, D., Huang, L., Zhang, J., Bian, Z., Chen, X., Liu, Y., Zhang, C.Y., and Zen, K. (2012). Argonaute 2 complexes selectively protect the circulating microRNAs in cell-secreted microvesicles. PLoS One 7: e46957.
77 Li, M., Zeringer, E., Barta, T., Schageman, J., Cheng, A., and Vlassov, A.V. (2014). Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 369 (1652): 20130502.
78 Li, Q., Kappil, M.A., Li, A., Dassanayake, P.S., Darrah, T.H., Friedman, A.E., Friedman, M., Lambertini, L., Landrigan, P., Stodgell, C.J., Xia, Y., Nanes, J.A., Aagaard, K.M., Schadt, E.E., Murray, J.C., Clark, E.B., Dole, N., Culhane, J., Swanson, J., Varner, M., Moye, J., Kasten, C., Miller, R.K., and Chen, J. (2015). Exploring the associations between microRNA expression profiles and environmental pollutants in human placenta from the National Children’s Study (NCS). Epigenetics 10: 793–802.
79 Li, T., Evdokimov, E., Shen, R.F., Chao, C.C., Tekle, E., Wang, T., Stadtman, E.R., Yang, D.C., and Chock, P.B. (2004). Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: A proteomic analysis. Proc. Natl. Acad. Sci. USA 101: 8551–8556.
80 Lin, J., Ma, L., Zhang, D., Gao, J., Jin, Y., Han, Z., and Lin, D. (2019). Tumour biomarkers: Tracing the molecular function and clinical implication. Cell Prolif. 52: e12589.
81 Liu, J.Q., Niu, Q., Hu, Y.H., Li, Y., Wang, H.X., Xu, S.Z., Ding, Y.S., Li, S.G., and Ma, R.L. (2018). The bidirectional effects of arsenic on miRNA-21: A systematic review and meta-analysis. Biomed. Environ. Sci. 31: 654–666.
82 Llewellyn, H.P., Vaidya, V.S., Wang, Z., Peng, Q., Hyde, C., Potter, D., Wang, J., Zong, Q., Arat, S., Martin, M., Masek-Hammerman, K., Warner, R., Johnson, K., Kullak-Ublick, G.A., Aithal, G.P., Dear, J.W., and Ramaiah, S.K. (2021). Evaluating the sensitivity and Specificity of promising circulating biomarkers to diagnose liver injury in humans. Toxicol. Sci. 181: 23–34.
83 Lopez-Sanchez, G.N., Dominguez-Perez, M., Uribe, M., Chavez-Tapia, N.C., and Nuno-Lambarri, N. (2021). Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease. Ann. Hepatol. 21: 100212.
84 Louwies, T., Jaki Mekjavic, P., Cox, B., Eiken, O., Mekjavic,
