T., Devanarayan, V., Leroy, B., Liguori, M.J., Blomme, E., Buck, W., and Maher, J. (2016). Evaluation of miR-122 as a serum biomarker for hepatotoxicity in investigative rat toxicology studies. Vet. Pathol. 53: 211–221.113 Sharma, S. and Lu, H.C. (2018). microRNAs in Neurodegeneration: Current findings and potential impacts. J. Alzheimers Dis. Parkinsonism 8.
114 Shurtleff, M.J., Temoche-diaz, M.M., Karfilis, K.V., Ri, S., and Schekman, R. (2016). Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. Elife 5.
115 Sima, M., Rossnerova, A., Simova, Z., and Rossner, P., JR. (2021). The impact of air pollution exposure on the microRNA machinery and lung cancer development. J. Pers. Med. 11 (1): 60. doi: 10.3390/jpm11010060.
116 Sisto, R., Capone, P., Cerini, L., Sanjust, F., Paci, E., Pigini, D., Gatto, M.P., Gherardi, M., Gordiani, A., L’Episcopo, N., Tranfo, G., and Chiarella, P. (2019). Circulating microRNAs as potential biomarkers of occupational exposure to low dose organic solvents. Toxicol. Rep. 6: 126–135.
117 Smith, A., Calley, J., Mathur, S., Qian, H.R., Wu, H., Farmen, M., Caiment, F., Bushel, P.R., Li, J., Fisher, C., Kirby, P., Koenig, E., Hall, D.G., and Watson, D.E. (2016). The rat microRNA body atlas: Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog. BMC Genom. 17: 694.
118 Sollome, J., Martin, E., Sethupathy, P., and Fry, R.C. (2016). Environmental contaminants and microRNA regulation: Transcription factors as regulators of toxicant-altered microRNA expression. Toxicol. Appl. Pharmacol. 312: 61–66.
119 Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., and Feng, F. (2016). Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Exp. Ther. Med. 12: 889–894.
120 Song, M.K. and Ryu, J.C. (2015). Blood miRNAs as sensitive and specific biological indicators of environmental and occupational exposure to volatile organic compound (VOC). Int. J. Hyg. Environ. Health 218: 590–602.
121 Sork, H., Corso, G., Krjutskov, K., Johansson, H.J., Nordin, J.Z., Wiklander, O.P.B., Lee, Y.X.F., Westholm, J.O., Lehtio, J., Wood, M.J.A., Mager, I., and El Andaloussi, S. (2018). Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome. Sci. Rep. 8: 10813.
122 Srinivasan, S., Yeri, A., Cheah, P.S., Chung, A., Danielson, K., De Hoff, P., Filant, J., Laurent, C.D., Laurent, L.D., Magee, R., Moeller, C., Murthy, V.L., Nejad, P., Paul, A., Rigoutsos, I., Rodosthenous, R., Shah, R.V., Simonson, B., To, C., Wong, D., Yan, I.K., Zhang, X., Balaj, L., Breakefield, X.O., Daaboul, G., Gandhi, R., Lapidus, J., Londin, E., Patel, T., Raffai, R.L., Sood, A.K., Alexander, R.P., Das, S., and Laurent, L.C. (2019). Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell 177 (446–462): e16.
123 Starkey Lewis, P.J., Dear, J., Platt, V., Simpson, K.J., Craig, D.G., Antoine, D.J., French, N.S., Dhaun, N., Webb, D.J., Costello, E.M., Neoptolemos, J.P., Moggs, J., Goldring, C.E., and Park, B.K. (2011). Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 54: 1767–1776.
124 Statello, L., Maugeri, M., Garre, E., Nawaz, M., Wahlgren, J., Papadimitriou, A., Lundqvist, C., Lindfors, L., Collen, A., Sunnerhagen, P., Ragusa, M., Purrello, M., Di Pietro, C., Tigue, N., and Valadi, H. (2018). Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes. PLoS One 13: e0195969.
125 Stermer, A.R., Reyes, G., Hall, S.J., and Boekelheide, K. (2019). Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol. Sci. 169: 399–408.
126 Straumfors, A., Duale, N., Foss, O.A.H., and Mollerup, S. (2020). Circulating miRNAs as molecular markers of occupational grain dust exposure. Sci. Rep. 10: 11317.
127 Tellez, C.S., Juri, D.E., Do, K., Bernauer, A.M., Thomas, C.L., Damiani, L.A., Tessema, M., Leng, S., and Belinsky, S.A. (2011). EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 71: 3087–3097.
128 Temoche-Diaz, M.M., Shurtleff, M.J., Nottingham, R.M., Yao, J., Fadadu, R.P., Lambowitz, A.M., and Schekman, R. (2019). Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes. eLife 8: e47544.
129 Thomas, R.S., Allen, B.C., Nong, A., Yang, L., Bermudez, E., and Clewell, H.J. 3RD, and Andersen, M.E. (2007). A method to integrate benchmark dose estimates with genomic data to assess the functional effects of chemical exposure. Toxicol. Sci. 98: 240–248.
130 Thompson, K.L., Boitier, E., Chen, T., Couttet, P., Ellinger-Ziegelbauer, H., Goetschy, M., Guillemain, G., Kanki, M., Kelsall, J., Mariet, C., De La Moureyre-Spire, C., Mouritzen, P., Nassirpour, R., O’Lone, R., Pine, P.S., Rosenzweig, B.A., Sharapova, T., Smith, A., Uchiyama, H., Yan, J., Yuen, P.S., and Wolfinger, R. (2016). Absolute measurement of cardiac injury-induced micrornas in biofluids across multiple test sites. Toxicol. Sci. 154: 115–125.
131 Thulin, P., Hornby, R.J., Auli, M., Nordahl, G., Antoine, D.J., Starkey Lewis, P., Goldring, C.E., Park, B.K., Prats, N., Glinghammar, B., and Schuppe-Koistinen, I. (2017). A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat. Biomarkers 22: 461–469.
132 Tomasetti, M., Gaetani, S., Monaco, F., Neuzil, J., and Santarelli, L. (2019). Epigenetic regulation of mirna expression in malignant mesothelioma: MiRNAs as biomarkers of early diagnosis and therapy. Front Oncol. 9: 1293.
133 Tribolet, L., Kerr, E., Cowled, C., Bean, A.G.D., Stewart, C.R., Dearnley, M., and Farr, R.J. (2020). MicroRNA biomarkers for infectious diseases: From basic research to biosensing. Front Microbiol. 11: 1197.
134 Tsamou, M., Vrijens, K., Madhloum, N., Lefebvre, W., Vanpoucke, C., and Nawrot, T.S. (2018). Air pollution-induced placental epigenetic alterations in early life: A candidate miRNA approach. Epigenetics 13: 135–146.
135 Tumolo, M.R., Panico, A., De Donno, A., Mincarone, P., Leo, C.G., Guarino, R., Bagordo, F., Serio, F., Idolo, A., Grassi, T., and Sabina, S. (2020). The expression of microRNAs and exposure to environmental contaminants related to human health: A review. Int. J. Environ. Health Res. (online, May 12): 1–23. doi: 10.1016/j.hoc.2021.05.005.
136 Turchinovich, A., Drapkina, O., and Tonevitsky, A. (2019). Transcriptome of Extracellular Vesicles: State-of-the-Art. Front Immunol. 10: 202.
137 Turchinovich, A., Weiz, L., Langheinz, A., and Burwinkel, B. (2011). Characterization of extracellular circulating microRNA. Nucleic Acids Res. 39: 7223–7233.
138 Valadi, H., Ekstrom, K., Bossios, A., Sjostrand, M., Lee, J.J., and Lotvall, J.O. (2007). Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9: 654–659.
139 Van Pottelberge, G.R., Mestdagh, P., Bracke, K.R., Thas, O., Van Durme, Y.M., Joos, G.F., Vandesompele, J., and Brusselle, G.G. (2011). MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 183: 898–906.
140 Vandana Saini, R.D, Suneja, S., Gangopadhyay, S., and Kaur, C. (2021). Can microRNA become next-generation tools in molecular diagnostics and therapeutics? A systematic review. Egypt. J. Med. Hum. Genet. 22: 1–9.
141 Vickers,
