Shamburek, R.D., and Remaley, A.T. (2011). MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell Biol. 13: 423–433.142 Vigneron, N., Meryet-Figuiere, M., Guttin, A., Issartel, J.P., Lambert, B., Briand, M., Louis, M.H., Vernon, M., Lebailly, P., Lecluse, Y., Joly, F., Krieger, S., Lheureux, S., Clarisse, B., Leconte, A., Gauduchon, P., Poulain, L., and Denoyelle, C. (2016). Towards a new standardized method for circulating miRNAs profiling in clinical studies: Interest of the exogenous normalization to improve miRNA signature accuracy. Mol. Oncol. 10: 981–992.
143 Villarroya-Beltri, C., Gutierrez-Vazquez, C., Sanchez-Cabo, F., Perez-Hernandez, D., Vazquez, J., Martin-Cofreces, N., Martinez-Herrera, D.J., Pascual-Montano, A., Mittelbrunn, M., and Sanchez-Madrid, F. (2013). Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat. Commun. 4: 2980.
144 Vogt, J., Sheinson, D., Katavolos, P., Irimagawa, H., Tseng, M., Alatsis, K.R., and Proctor, W.R. (2019). Variance component analysis of circulating miR-122 in serum from healthy human volunteers. PLoS One 14: e0220406.
145 Vrijens, K., Bollati, V., and Nawrot, T.S. (2015). MicroRNAs as potential signatures of environmental exposure or effect: A systematic review. Environ. Health Perspect. 123: 399–411.
146 Wallace, D.R., Taalab, Y.M., Heinze, S., Tariba Lovakovic, B., Pizent, A., Renieri, E., Tsatsakis, A., Farooqi, A.A., Javorac, D., Andjelkovic, M., Bulat, Z., Antonijevic, B., and Buha Djordjevic, A. (2020). Toxic-metal-induced alteration in miRNA expression profile as a proposed mechanism for disease development. cells 9.
147 Wang, G.K., Zhu, J.Q., Zhang, J.T., Li, Q., Li, Y., He, J., Qin, Y.W., and Jing, Q. (2010a). Circulating microRNA: A novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur. Heart. J. 31: 659–666.
148 Wang, J., Zhang, Y., Zhang, W., Jin, Y., and Dai, J. (2012). Association of perfluorooctanoic acid with HDL cholesterol and circulating miR-26b and miR-199-3p in workers of a fluorochemical plant and nearby residents. Environ. Sci. Technol. 46: 9274–9281.
149 Wang, K., Zhang, S., Marzolf, B., Troisch, P., Brightman, A., Hu, Z., Hood, L.E., and Galas, D.J. (2009). Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl. Acad. Sci. USA 106: 4402–4407.
150 Wang, M., Ye, Y., Qian, H., Song, Z., Jia, X., Zhang, Z., Zhou, J., and Ni, C. (2010b). Common genetic variants in pre-microRNAs are associated with risk of coal workers’ pneumoconiosis. J. Hum. Genet. 55: 13–17.
151 Wang, T., Xu, H., Qi, M., Yan, S., and Tian, X. (2018). miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: A systematic review and meta-analysis. Oncotarget 9: 5473–5479.
152 Wang, W., Zhang, H., Duan, X., Feng, X., Wang, T., Wang, P., Ding, M., Zhou, X., Liu, S., Li, L., Liu, J., Tang, L., Niu, X., Zhang, Y., Li, G., Yao, W., and Yang, Y. (2019). Association of genetic polymorphisms of miR-145 gene with telomere length in omethoate-exposed workers. Ecotoxicol. Environ. Saf. 172: 82–88.
153 Weber, D.G., Johnen, G., Bryk, O., Jockel, K.H., and Bruning, T. (2012). Identification of miRNA-103 in the cellular fraction of human peripheral blood as a potential biomarker for malignant mesothelioma–a pilot study. PLoS One 7: e30221.
154 Weber, J.A., Baxter, D.H., Zhang, S., Huang, D.Y., Huang, K.H., Lee, M.J., Galas, D.J., and Wang, K. (2010). The microRNA spectrum in 12 body fluids. Clin. Chem. 56: 1733–1741.
155 Webster, A.F., Chepelev, N., Gagne, R., Kuo, B., Recio, L., Williams, A., and Yauk, C.L. (2015). Impact of genomics platform and statistical filtering on transcriptional benchmark doses (BMD) and multiple approaches for selection of chemical point of departure (PoD). PLoS One 10: e0136764.
156 Weldon, B.A., Shubin, S.P., Smith, M.N., Workman, T., Artemenko, A., Griffith, W.C., Thompson, B., and Faustman, E.M. (2016). Urinary microRNAs as potential biomarkers of pesticide exposure. Toxicol. Appl. Pharmacol. 312: 19–25.
157 World Health Organization and International Programme on Chemical Safety (1993). Biomarkers and Risk Assessment: Concepts and Principles, published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. World Health Organization. https://apps.who.int/iris/handle/10665/39037.
158 Xu, M., Yu, Z., Hu, F., Zhang, H., Zhong, L., Han, L., An, Y., Zhu, B., and Zhang, H. (2017). Identification of differential plasma miRNA profiles in Chinese workers with occupational lead exposure. Biosci. Rep. 37.
159 Yamamoto, M., Singh, A., Sava, F., Pui, M., Tebbutt, S.J., and Carlsten, C. (2013). MicroRNA expression in response to controlled exposure to diesel exhaust: Attenuation by the antioxidant N-acetylcysteine in a randomized crossover study. Environ. Health Perspect. 121: 670–675.
160 Yanshina, D.D., Kossinova, O.A., Gopanenko, A.V., Krasheninina, O.A., Malygin, A.A., Venyaminova, A.G., and Karpova, G.G. (2018). Structural features of the interaction of the 3ʹ-untranslated region of mRNA containing exosomal RNA-specific motifs with YB-1, a potential mediator of mRNA sorting. Biochimie. 144: 134–143.
161 Yauk, C.L., Rowan-carroll, A., Stead, J.D., and Williams, A. (2010). Cross-platform analysis of global microRNA expression technologies. BMC Genom. 11: 330.
162 Yu, H.W. and Cho, W.C. (2015). The role of microRNAs in toxicology. Arch. Toxicol. 89: 319–325.
163 Yuan, H., Yuan, M., Tang, Y., Wang, B., and Zhan, X. (2018). MicroRNA expression profiling in human acute organophosphorus poisoning and functional analysis of dysregulated miRNAs. Afr. Health Sci. 18: 333–342.
164 Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Sun, F., Lu, J., Yin, Y., Cai, X., Sun, Q., Wang, K., Ba, Y., Wang, Q., Wang, D., Yang, J., Liu, P., Xu, T., Yan, Q., Zhang, J., Zen, K., and Zhang, C.Y. (2010). Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol. Cell 39: 133–144.
165 Zhou, S.S., Jin, J.P., Wang, J.Q., Zhang, Z.G., Freedman, J.H., Zheng, Y., and Cai, L. (2018). miRNAS in cardiovascular diseases: Potential biomarkers, therapeutic targets and challenges. Acta Pharmacol. Sin. 39: 1073–1084.
166 Zhou, X., Wang, L., Zou, W., Chen, X., Roizman, B., and Zhou, G.G. (2020). hnRNPA2B1 Associated with recruitment of RNA into exosomes plays a key role in herpes simplex virus 1 release from infected cells. J. Virol. 94 (3): e00367-20.
3 EV (Extracellular Vesicle)-associated miRNAs as Biomarkers of Toxicity
Ryuichi Ono1*, Yusuke Yoshioka2, Yusuke Furukawa1, Mie Naruse1,3, Makiko Kuwagata1, Takahiro Ochiya1,2,4, Satoshi Kitajima1, and Yoko Hirabayashi5
1 Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research, National Institute of Health Sciences (NIHS)
2 Division of Molecular and Cellular Medicine, Institute of Medical Science, Tokyo Medical University
3 Central Animal Division, National Cancer Center Research Institute
4 Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
5 Center for Biological Safety and Research, National Institute of Health Sciences (NIHS)
Introduction
