Secondary Metabolites of Medicinal Plants. Bharat Singh
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Benzofuran derivatives such as 2-(2′-methylethyl)-5,6-dimethoxybenzofuran and 14-hydroxy-2Hβ,3-dihydroeuparine (Ahmed et al. 1999) as well as chromone derivatives, 3-(2′-methylpropyl)-2-methyl-6,8-dimethoxychrom-4-one and 2-(2′-methylprop-2′-enyl)-2-methyl-6,7-dimethoxychroman-4-one, have also been identified from this plant species (Pari et al. 1998). Besides benzofuran derivatives, the triterpenes such as friedelin, β-sitosterol, stigmasterol, brassicasterol, dihydrobrassicasterol, spinasterol, dihydrospinasterol, lycopsamine, echinatine, (+)-sesamin, aurantiamide acetate, fumaric acid, caffeic acid, phytol and hydrocarbons, (nC27–H56 to nC32–H66) have also been isolated from A. conyzoides (Wiedenfeld and Roder 1991; Riaz et al. 1991).
Ageratum conyzoides is very rich in polyoxygenated flavonoids (González et al. 1991b; Vyas and Mulchandani 1986; González et al. 1984; Quijano 1980a,b; Adesogan and Okunade 1978, 1979; Horie et al. 1993), 3′,4′,5′-oxygenated flavones, 5′-methoxynobiletin, linderoflavone B, 5,6,7,3′,4′,5′-hexamethoxyflavone, 5,6,8,3′,4′,5′-hexamethoxyflavone, eupalestin (González et al. 1991a; Vyas and Mulchandani 1986), scutellarein-5,6,7,4′-tetrahydroxyflavone, quercetin, quercetin-3-rhamnopyranoside, kaempferol, kaempferol-3-rhamnopyranoside, and kaempferol 3,7-diglucopyranoside (Gill et al. 1978; Nair et al. 1977; Yadara and Kumar 1999). The coumarins such as ageratochromene, β-caryophyllene, caffeic acid, caryophyllene epoxide, echinatine, eugenol, fumaric acid, kaempferol-3,7-diglucopyranoside, precocene I, precocene II α-pinene, β-pinene, δ-cadinene, 2-(1′-oxo-2′-methylpropyl)-2-methyl-6,7-dimethoxy-chromene, 2-(2′-methylprop-2′-enyl)-2-methyl-6,7-dimethoxychroman-19-one, -(2′-methylpropyl)-2-methyl-6,8-dimethoxychrom-19-one,2-(2′-methylethyl)-5,6-dimethoxybenzofuran, 5,7,2′,19′-tetrahydroxy-6,3′-di-(3,3-dimethylallyl)-isoflavone, 5-O-α-l-rhamnopyrosyl-(1→19)-α-l-rhamnopyranoside, methyl-6,7-dimethoxy chromene have been reported from A. conyzoides (Singh et al. 2013; Kupriyanova 1997; Adebayo et al. 2010a,b), encecalol and demethoxyencecalol (González et al. 1991b), sesamin (Moazzami et al. 2007), linderoflavone B (Saxena and Shrivastava 1994), 3′-hydroxy-5,6,7,8,4′,5′-hexamethoxyflavone (Herz and Kulanthaivel 1982), 5′-methoxynobiletin (Le-Van and Van Cuong Pham 1979; Herz et al. 1980), and 2-hydroxycinnamic and 2-hydroxydihydrocinnamic acids have been reported from A. conyzoides (Gerothanassis et al. 1998). The lycopsamine, lycopsamine N-oxide, dihydrolycopsamine, dihydrolycopsamine N-oxide, acetyllycopsamine, and acetyllycopsamine N-oxide were isolated from A. conyzoides (Okunade 2002; Bosi et al. 2013).
2.7.2 Culture Conditions
The hairy roots of A. conyzoides were established with Agrobacterium rhizogenes for increasing the production of chromenes. The main compounds as β-farnesene, precocene I, and β-caryophyllene were estimated and enhanced in production in the presence of light conditions and also on the age of cultures. Precocene I, β-farnesene, precocene II, and β-caryophyllene are the main compounds of the volatile oils from the parent plant