Papilloma
•Bloody Nipple Discharge
•Unilateral
Lobular Carcinoma
•Pre-menopausal female
•Mostly bilateral
•Multifocal
Ductal Carcinoma
•Unilateral
•Most common malignant
Fibrocystic Disease (Disorder)
•Age 25-50
•Most common breast disorder
•Bilateral pain
•Apocrine metaplasia
•Fibrosis and sclerosing adenosis
•Cysts
•Often benign
•Regression with pregnancy
Fibroadenoma
•20-30 years age
•Intracanalicular and pericanalicular Fibroadenoma
•Increased sensitivity to estrogen
•Benign focal tumor
Other Breast Conditions
•Acute Mastitis ⇔ Staph aureus
•Medullary carcinoma ⇔ Fleshy texture
•Mucinous carcinoma ⇔ Gelatinous texture
•Paget’s ⇔ Poor prognosis, ductal carcinoma, older women, nipples
Ovarian Tumors
•Granulosa tumor ⇔ estrogen
•Arrhenoblastoma ⇔ Sertoli
•Cystadenoma ⇔ Pseudomyxoma
•Dysgerminoma ⇔ Seminoma, radiosensitive
•Krukenberg’s ⇔ Metastatic ovarian; Signet-ring
•Fibroma ⇔ Meig’s syndrome
•Choriocarcinoma ⇔ HCG
•Dermoid Cysts ⇔ Mature teratoma
Infectious (Reproductive) Conditions
•Trichomoniasis ⇔ malodorous vaginitis, “strawberry cervix”
•Candidiasis ⇔ Pruritic white thick discharge, mostly coitus related, HIV positive
•Gardnerella vaginalis ⇔ Clue cells
•Chlamydia ⇔ Asymptomatic PID
•Lymphogranuloma venereum ⇔ Rectal stricture
•Toxic shock syndrome ⇔ Staph aureus tampons.
•Gonorrhea ⇔ N. gonorrhea PID
•Herpes (HSV) ⇔ Multinucleated giant cells
•Granuloma inguinale (Calymmatobacterium granulomatis) ⇔ Donovan bodies
•Syphilis ⇔ condyloma lata, VDRL, FTA-abs, tabes dorsalis
•Chancroids ⇔ Haemophilus ducreyi
Cervical Carcinoma
•Related to HPV types 16 and 18
•Dysplasia
•Squamous cell carcinoma
•Squamo-columnar junction
•Post-coital bleeding
Others
•Vaginal Clear Cell ⇔ DES in utero
•Mucinous cystadenocarcinoma ⇔ Pseudomyxoma peritonei
•Serous Cystadenoma ⇔ Psammoma bodies
•Hydatidiform ⇔ HCG
•Choriocarcinoma ⇔ Lung metastasis
12. SKIN-RELATED CONDITIONS
Psoriasis
•More in men
•Auspitz
•Spongiform pustule of Kogoj
•Munro’s micro-abscess
•7% of patients with arthritis
•Autosomal dominance
Erythema Multiforme
•Target lesion
•A.K.A. Steven Johnson syndrome
•Recurrence
•“Iris lesion”
Pemphigus Vulgaris
•40-60 years age
•Jewish population
•Intra-epidermal bullae
•Keratinocytes with IgG
•Ethanol Abuse
Bullous Pemphigoid
•60+ age
•Linear IgG in basement membrane
Basal Cell Carcinoma
•Most common skin neoplasm
•Mostly face and scalp
•Pearly border
•Palisading
•Sunlight
Kaposi’s Sarcoma
•More in men
•Children
•Lower extremities with or without visceral involvement
•AIDS
